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किडनी फेल होने पर खून में अपशिष्ट (यूरिया सहित) जमा होना — लक्षण: थकान, भूख न लगना, मतली, खुजली, सोच में भ्रम। गंभीर यूरेमिया में डायलिसिस की आवश्यकता होती है।
Uremia (literally 'urine in the blood') develops when the kidneys fail to excrete metabolic wastes, leading to systemic toxicity. Early symptoms include fatigue, anorexia, nausea, and pruritus. Advanced uremia manifests as pericarditis, encephalopathy (asterixis, seizures, coma), bleeding diathesis, and serositis. The uremic syndrome involves accumulation of urea, creatinine, phenols, indoles, beta-2 microglobulin, and middle molecules. Dialysis initiation is typically recommended when eGFR falls to 5-10 mL/min/1.73m² with uremic symptoms (IDEAL trial, Cooper et al., 2010, NEJM). Uremic symptoms should improve significantly within 2-4 weeks of adequate dialysis.
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This content is a general reference, not medical advice, a diagnosis, or a treatment plan. Do not change your diet, fluids, medicines, or dialysis plan without your nephrologist or renal dietitian. Individual recommendations depend on your labs, medications, conditions, and care plan.