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Kidney injury caused by NSAIDs (ibuprofen, diclofenac, naproxen) — a leading preventable cause of AKI and CKD progression.
NSAIDs block prostaglandins that maintain kidney blood flow, causing acute kidney injury, fluid retention, and accelerated CKD progression. They are especially dangerous with dehydration, heart failure, advanced age, and concurrent RAAS inhibitors or diuretics (the 'triple whammy'). Avoid in CKD stages 3b-5; paracetamol is the safer analgesic.
A sudden drop in kidney function over hours to days - reversible if caught early, but a major risk factor for chronic kidney disease.
High potassium in the blood — a common and potentially dangerous complication of CKD, especially with ACEi/ARB therapy — causing heart rhythm disturbances at severe levels.
Excess extracellular fluid volume in kidney patients from inadequate excretion, causing edema, hypertension, pulmonary congestion, and increased cardiovascular risk.
The bidirectional failure of heart and kidneys — one organ's dysfunction worsens the other.
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This content is a general reference, not medical advice, a diagnosis, or a treatment plan. Do not change your diet, fluids, medicines, or dialysis plan without your nephrologist or renal dietitian. Individual recommendations depend on your labs, medications, conditions, and care plan.