A leading cause of nephrotic syndrome in adults — antibodies attacking the glomerular basement membrane.
Membranous nephropathy is often primary (anti-PLA2R antibodies) or secondary (cancer, lupus, hepatitis B, drugs). It presents with heavy proteinuria and edema; one third remit spontaneously, one third progress. Risk-stratified treatment (RAAS blockade, rituximab, calcineurin inhibitors) depends on proteinuria level and antibody titers.
Heavy protein loss in urine (proteinuria >3.5 g/day) with low albumin, edema, and high cholesterol - a hallmark of glomerular disease.
Abnormal presence of protein in the urine, a key marker of kidney damage and the strongest predictor of CKD progression and cardiovascular risk.
Inflammation of the kidney's filtering units (glomeruli) - a diverse family of diseases often presenting with blood and protein in urine.
Kidney inflammation caused by systemic lupus erythematosus — a major cause of morbidity in SLE.
A procedure that takes a tiny sample of kidney tissue for a microscope to diagnose glomerular disease, guide treatment, and assess injury or rejection.
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This content is a general reference, not medical advice, a diagnosis, or a treatment plan. Do not change your diet, fluids, medicines, or dialysis plan without your nephrologist or renal dietitian. Individual recommendations depend on your labs, medications, conditions, and care plan.