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A waste product of muscle metabolism filtered by the kidneys; serum creatinine levels are used to estimate GFR and monitor kidney function over time.
Creatinine is produced from creatine in muscle at a relatively constant rate and excreted by glomerular filtration. Rising serum creatinine indicates falling filtration, but the relationship is non-linear — small creatinine rises reflect large GFR losses early on. Normal values vary by muscle mass, age, and sex (typically 0.6-1.2 mg/dL in adults). Serum creatinine feeds into eGFR equations (CKD-EPI, MDRD) that stage CKD. Limitations: creatinine is affected by muscle mass, protein intake, creatine supplements, hydration, and some drugs (trimethoprim, cimetidine). Use the eGFR calculator to convert creatinine to estimated filtration rate.
A calculated value estimating the rate at which kidneys filter blood, used to diagnose and stage chronic kidney disease.
A progressive condition characterized by gradual loss of kidney function over months or years, classified into 5 stages based on eGFR.
The medical specialty focused on the diagnosis, treatment, and management of kidney diseases, including dialysis and transplant care.
Abnormal presence of protein in the urine, a key marker of kidney damage and the strongest predictor of CKD progression and cardiovascular risk.
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This content is a general reference, not medical advice, a diagnosis, or a treatment plan. Do not change your diet, fluids, medicines, or dialysis plan without your nephrologist or renal dietitian. Individual recommendations depend on your labs, medications, conditions, and care plan.