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An advanced dialysis modality combining hemodialysis (diffusion) with hemofiltration (convection) to enhance clearance of both small and middle molecular weight solutes.
Hemodiafiltration (HDF) combines diffusive clearance (as in standard HD) with convective clearance via ultrafiltration and simultaneous substitution fluid replacement. Online HDF (ol-HDF) uses freshly generated ultrapure dialysate as substitution fluid. The ESHOL study (Maduell et al., 2013, JASN) demonstrated a 30% reduction in all-cause mortality with high-volume HDF (convective volume >23 L/session) compared to standard HD. Other trials (CONTRAST, Turkish HDF Study) showed trends toward improved survival in subgroups. Key parameters include substitution volume target (≥23 L/session for post-dilution HDF), ultrapure dialysate (endotoxin <0.03 EU/mL), and convective clearance monitoring.
A medical procedure that filters waste products, excess fluids, and toxins from the blood using a dialysis machine when the kidneys can no longer perform this function adequately.
The process of removing excess fluid from a patient's blood during dialysis by applying pressure across the dialyzer membrane.
The artificial kidney component of a dialysis machine containing a semipermeable membrane that filters waste and excess fluid from blood.
The specially formulated solution used in dialysis that draws waste products and excess electrolytes from the blood across the dialyzer membrane.
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This content is a general reference, not medical advice, a diagnosis, or a treatment plan. Do not change your diet, fluids, medicines, or dialysis plan without your nephrologist or renal dietitian. Individual recommendations depend on your labs, medications, conditions, and care plan.